Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types

SP Kar; J Beesley; AA Al Olama; K Michailidou; J Tyrer; ZA Kote-Jarai; K Lawrenson; S Lindstrom; SJ Ramus; DJ Thompson; AS Kibel; A Dansonka-Mieszkowska; A Michael; AK Dieffenbach; A Gentry-Maharaj; AS Whittemore; A Wolk; A Monteiro; A Peixoto; A Kierzek; A Cox; A Rudolph; A Gonzalez-Neira; AH Wu; A Lindblom; A Swerdlow; A Ziogas; AB Ekici; B Burwinkel; BY Karlan; BG Nordestgaard; C Blomqvist; C Phelan; C McLean; CL Pearce; C Vachon; C Cybulski; C Slavov; C Stegmaier; C Maier; CB Ambrosone; CK Hogdall; CC Teerlink; D Kang; DC Tessier; DJ Schaid; DO Stram; DW Cramer; DE Neal; D Eccles; D Flesch-Janys; DR Velez Edwards; D Wokozorczyk; DA Levine; D Yannoukakos; EJ Sawyer; EV Bandera; EM Poole; EL Goode; E Khusnutdinova; E Hogdall; F Song; F Bruinsma; F Heitz; F Modugno; FC Hamdy; F Wiklund; GG Giles; H Olsson; H Wildiers; HU Ulmer; H Pandha; HA Risch; H Darabi; HB Salvesen; H Nevanlinna; H Gronberg; H Brenner; H Brauch; H Anton-Culver; H Song; HY Lim; I McNeish; I Campbell; I Vergote; J Gronwald; J Lubiński; JL Stanford; J Benitez; JA Doherty; JB Permuth; J Chang-Claude; JL Donovan; J Dennis; JM Schildkraut; J Schleutker; JL Hopper; J Kupryjanczyk; JY Park; J Figueroa

Journal article

Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types

SP Kar, J Beesley, AA Al Olama, K Michailidou, J Tyrer, ZA Kote-Jarai, K Lawrenson, S Lindstrom, SJ Ramus, DJ Thompson, AS Kibel, A Dansonka-Mieszkowska, A Michael, AK Dieffenbach, A Gentry-Maharaj, AS Whittemore, A Wolk, A Monteiro, A Peixoto, A Kierzek Show all

Cancer Discovery | AMER ASSOC CANCER RESEARCH | Published : 2016

DOI: 10.1158/2159-8290.CD-15-1227

Abstract

Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/ BCL2L11; rs7937840/11q12/ INCENP; rs1469713/19p13/ GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/ SMC2; rs8037137/15q26/ RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p3..

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University of Melbourne Researchers

Fiona Bruinsma Author

Graham Giles Author

Melissa Southey Author

Robert MacInnis Author

Grants

Awarded by Breast Cancer Research Foundation

Funding Acknowledgements

The Breast Cancer Association Consortium (BCAC), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), and the Ovarian Cancer Association Consortium (OCAC) that contributed breast, prostate, and ovarian cancer data analyzed in this study were in part funded by Cancer Research UK (C1287/A10118 and C1287/A12014 for BCAC; C5047/A7357, C1287/A10118, C5047/A3354, C5047/A10692, and C16913/A6135 for PRACTICAL; and C490/A6187, C490/A10119, C490/A10124, C536/A13086, and C536/A6689 for OCAC). Funding for the Collaborative Oncological Gene-Environment Study (COGS) infrastructure came from the European Community's Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, and C8197/A16565), the NIH (CA128978) and the Post-Cancer GWAS Genetic Associations and Mechanisms in Oncology (GAME-ON) initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112), the U.S. Department of Defense (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund [with donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07)]. Additional financial support for contributing studies is documented in the Supplementary Financial Support.